Tapentadol price

Available in: 0 Pharmacy(s)

Instructions for use Tapentadol



Bioavailability: 0-50%

ATC-Code: N02AX06

Protein binding: ≥ 20%

Metabolism: No data available


Half-life: 4 hours

Excretion: Urine

CAS number: 175591-09-0

PubChem-CID: 9838022

ChemSpider: 8013742

UNII: H8A007M585

KEGG: D06007

ChEMBL: ChEMBL1201776

ECHA-InfoCard: 100.131.247

Formula: C14H23NO

Molar mass: 221.344 g·mol−1

How does it work?

Tapentadol is a centrally acting analgesic that combines two mechanisms of action in one molecule, namely μ-opioid receptor agonism and norepinephrine reuptake inhibition.

μ-receptor agonists work by altering the emotional and sensory aspects of pain, inhibiting the transmission of pain to the spinal cord, and affecting activities in the parts of the brain responsible for pain perception. As a norepinephrine reuptake inhibitor, it increases the level of norepinephrine in the brain.

The effectiveness is comparable to morphine. However, tapentadol appears to be better tolerated, particularly in terms of digestive side effects such as vomiting, nausea and constipation.

How is it used?

The tablets tapentadol are taken orally in an initial dose of 50 mg twice a day. It is taken with water, 12 hours apart and independent of meals.

The dose should be set individually by the doctor, depending on the severity of the pain syndrome and the previous therapy.

Side effects






Warnings and Precautions

Beware of the liver problems

Beware of kidney problems

Be careful with epilepsy

Caution when taking or using certain medicines

Mixed µ-opioid receptor agonists/antagonists (e.g. nalbuphine, pentazocine) and partial µ-opioid receptor agonists (buprenorphine).

Drug abuse

Drug addiction

Other trade names

Palexia Yantil Nucynta

Compare medications


Hypersensitivity to the ingredients

Acute intoxication with alcohol, painkillers and sleeping pills or medication for certain mental illnesses

Intestinal paralysis


Respiratory depression



Not safe


Alcohol consumption increases the side effects of medication

What happens if you miss the dose?

Do not apply a double dose if you have forgotten the previous application, but continue as before.


Serious side effects can occur after taking excessively high doses. If you experience severe side effects, seek medical help immediately.


There is a risk of serious interactions. Therefore, regular medical monitoring is required.

Unwanted reactions


Dry mouth




Food does not affect the effects of the drug.


Keep this medicine out of the sight and reach of children.

This medicinal product does not require special storage conditions.

Frequently Asked Questions

How long does tapentadol work?

The effects of tapentadol last 4 to 6 hours.

What is the maximum daily dose of tapentadol?

The maximum dose is 500 mg tapentadol per day and should never be exceeded.

Is tapentadol a BTM?

Tapentadol requires a prescription in Britain. It is subject to the BtMVV (Narcotics Prescription Ordinance). Therefore, one needs a valid prescription if one wants to buy Tapentadol. Treatment with tapentadol may only be carried out on special medical prescription and instruction.

How dangerous is tapentadol?

Tapentadol preparations can lead to side effects at the beginning of the intake. For example, patients may experience dizziness, drowsiness, and blurred vision.

Can Tapentadol Cause Addiction?

Yes, tapentadol can be addictive. Drugs containing tapentadol have the potential for dependency and abuse.

What is tapentadol?

Tapentadol is a centrally acting analgesic belonging to the group of opioid analgesics. It is used to treat moderate and severe pain that can only be adequately managed with opioid analgesics.

Tapentadol is classified as a prescription narcotic in Britain. In Britain, this opioid analgesic was launched in 2010 in the form of prolonged-release tablets. It will be available as an oral solution throughout Britain from 2014. It is also available as immediate-release tablets.

There are two reasons why tapentadol is remarkable. First, it has two synergistic mechanisms of action, meaning it binds to μ-opioid receptors in the body to block pain and inhibits norepinephrine reuptake from the synaptic cleft. Second, tapentadol is the first centrally acting synthetic analgesic.

When is tapentadol suitable?

The drug is used only for moderate or severe pain that can only be adequately managed with opioid analgesics.

Osteoarthritis, diabetic neuropathy and back pain are the ailments for which tapentadol can be prescribed. As a rule, it is not recommended for respiratory diseases such as asthma. It is also not suitable for patients with severe kidney or liver disease.

In what dosage and dosage form can you buy tapentadol?

You can buy the painkiller Tapentadol under the trade name Palexia in 3 dosage forms. There are 50 mg, 100 mg, 150 mg, 200 mg and 250 mg prolonged release tablets, immediate release tablets and oral solution on the market.

What should you tell your doctor before taking tapentadol?

Tell your doctor if you have the following symptoms:

  • Allergy to tapentadol, any of its ingredients, other medicines, foods or substances.
  • Lung diseases or breathing problems such as bronchial asthma, breathing difficulties or sleep apnea
  • hypercapnia (increased levels of carbon dioxide in the blood);
  • intestinal obstruction
  • kidney or liver disease

Tell your doctor and pharmacist about all medicines you are taking (both prescription and over-the-counter medicines, natural remedies, and vitamins). Tapenpadol may interact with other medications.

This should be taken into account

This drug has the potential for addiction and abuse. This should be taken into account when prescribing a medicine containing tapentadol.

At high doses and in patients with hypersensitivity to agonists of the µ-opioid receptors, tapentadol can induce dose-dependent respiratory depression.

Tapentadol should not be prescribed to patients who are particularly sensitive to pathophysiological reactions.

This preparation can cause sphincter of Oddi dysfunction.

Tapentadol should be used with caution in patients with biliary tract disease, traumatic brain injury, brain tumor and acute pancreatitis.

Special caution is required in the case of adrenal insufficiency (e.g. in Addison's disease), alcoholic delirium, myxedema, toxic psychosis, hypothyroidism, as well as prostatic hypertrophy and urethral strictures.

Stopping tapentadol (Palexia, Nucynta) suddenly can develop withdrawal symptoms such as: B. Anxiety, excessive sweating, chills, pain, insomnia, nausea, tremors, diarrhea, piloerection and rarely hallucinations. To prevent withdrawal symptoms, the dose of the drug should be reduced gradually.

It should be noted that this preparation can cause a significant drop in blood pressure. Patients with hypovolemia or those taking tapentadol concomitantly with phenothiazine derivatives or anesthetics are particularly susceptible.

A life-threatening serotonin syndrome can develop if tapentadol is taken concomitantly with serotonergic drugs. These drugs are selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, triptans, drugs that affect serotonergic transmission in the central nervous system (e.g., mirtazapine, trazodone, and tramadol tablets), and drugs that inhibit serotonin metabolism (e.g., MAO- inhibitors). Possible symptoms of serotonin syndrome include: confusion, restlessness, coma, tachycardia, fever, impaired motor coordination, nausea, vomiting and diarrhea.

Due to an increased risk of seizures, tapentadol should be used with caution in patients with a history of seizures or epilepsy.

What serious side effects can occur?

In rare cases, some patients can experience serious and sometimes fatal side effects. Call your doctor or see a doctor straight away if you have any of the following signs or symptoms, which could cause serious side effects:

  • Signs of an allergic reaction such as rash, itching, hives, swollen skin with blisters or scales, wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, swelling of the face, lips, tongue or throat, swelling in the mouth;
  • Severe dizziness or fainting;
  • Cramps;
  • Severe constipation or abdominal pain. These can be signs of a serious bowel disorder;
  • Chest pain or pressure, or a fast heartbeat.
  • Sleep apnea syndrome;
  • shortness of breath
  • Aberration;
  • Gait disturbances;
  • Mood swings.


  1. arznei-telegramm.de (2010): Opioid analgesic tapentadol (Palexia retard). In: at 2010;41; 103-4.
  2. gel-liste.de: Specialist information: active ingredient tapentadol
  3. Tzschentke TM et al. Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule. Drugs Today (Barc), 2009, 45(7), 483-96
  4. patient.info: Tapentadol for pain relief

Tapentadol price



1 Review(s)

Leave a review

Palexia was prescribed by my doc for severe osteoarthritis. Here it is important to find the right dose. I take 150 mg tapendapol and I`m fine with it. Thank goodness the headache didn`t last long.


Leave a review



This site is protected by reCAPTCHA and the Data protection and Terms of Use from Google.