Tapentadol price

What is tapentadol?

Tapentadol is a centrally acting analgesic belonging to the group of opioid analgesics. It is used to treat moderate and severe pain that can only be adequately managed with opioid analgesics.

Tapentadol is classified as a prescription narcotic in Britain. In Britain, this opioid analgesic was launched in 2010 in the form of prolonged-release tablets. It will be available as an oral solution throughout Britain from 2014. It is also available as immediate-release tablets.

There are two reasons why tapentadol is remarkable. First, it has two synergistic mechanisms of action, meaning it binds to μ-opioid receptors in the body to block pain and inhibits norepinephrine reuptake from the synaptic cleft. Second, tapentadol is the first centrally acting synthetic analgesic.

When is tapentadol suitable?

The drug is used only for moderate or severe pain that can only be adequately managed with opioid analgesics.

Osteoarthritis, diabetic neuropathy and back pain are the ailments for which tapentadol can be prescribed. As a rule, it is not recommended for respiratory diseases such as asthma. It is also not suitable for patients with severe kidney or liver disease.

In what dosage and dosage form can you buy tapentadol?

You can buy the painkiller Tapentadol under the trade name Palexia in 3 dosage forms. There are 50 mg, 100 mg, 150 mg, 200 mg and 250 mg prolonged release tablets, immediate release tablets and oral solution on the market.

What should you tell your doctor before taking tapentadol?

Tell your doctor if you have the following symptoms:

• Allergy to tapentadol, any of its ingredients, other medicines, foods or substances.
• Lung diseases or breathing problems such as bronchial asthma, breathing difficulties or sleep apnea
• hypercapnia (increased levels of carbon dioxide in the blood);
• intestinal obstruction
• kidney or liver disease

Tell your doctor and pharmacist about all medicines you are taking (both prescription and over-the-counter medicines, natural remedies, and vitamins). Tapenpadol may interact with other medications.

This should be taken into account

This drug has the potential for addiction and abuse. This should be taken into account when prescribing a medicine containing tapentadol.

At high doses and in patients with hypersensitivity to agonists of the µ-opioid receptors, tapentadol can induce dose-dependent respiratory depression.

Tapentadol should not be prescribed to patients who are particularly sensitive to pathophysiological reactions.

This preparation can cause sphincter of Oddi dysfunction.

Tapentadol should be used with caution in patients with biliary tract disease, traumatic brain injury, brain tumor and acute pancreatitis.

Special caution is required in the case of adrenal insufficiency (e.g. in Addison's disease), alcoholic delirium, myxedema, toxic psychosis, hypothyroidism, as well as prostatic hypertrophy and urethral strictures.

Stopping tapentadol (Palexia, Nucynta) suddenly can develop withdrawal symptoms such as: B. Anxiety, excessive sweating, chills, pain, insomnia, nausea, tremors, diarrhea, piloerection and rarely hallucinations. To prevent withdrawal symptoms, the dose of the drug should be reduced gradually.

It should be noted that this preparation can cause a significant drop in blood pressure. Patients with hypovolemia or those taking tapentadol concomitantly with phenothiazine derivatives or anesthetics are particularly susceptible.

A life-threatening serotonin syndrome can develop if tapentadol is taken concomitantly with serotonergic drugs. These drugs are selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, triptans, drugs that affect serotonergic transmission in the central nervous system (e.g., mirtazapine, trazodone, and tramadol tablets), and drugs that inhibit serotonin metabolism (e.g., MAO- inhibitors). Possible symptoms of serotonin syndrome include: confusion, restlessness, coma, tachycardia, fever, impaired motor coordination, nausea, vomiting and diarrhea.

Due to an increased risk of seizures, tapentadol should be used with caution in patients with a history of seizures or epilepsy.

What serious side effects can occur?

In rare cases, some patients can experience serious and sometimes fatal side effects. Call your doctor or see a doctor straight away if you have any of the following signs or symptoms, which could cause serious side effects:

• Signs of an allergic reaction such as rash, itching, hives, swollen skin with blisters or scales, wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, swelling of the face, lips, tongue or throat, swelling in the mouth;
• Severe dizziness or fainting;
• Cramps;
• Severe constipation or abdominal pain. These can be signs of a serious bowel disorder;
• Chest pain or pressure, or a fast heartbeat.
• Sleep apnea syndrome;
• shortness of breath
• Aberration;
• Gait disturbances;
• Mood swings.

Resources

1. arznei-telegramm.de (2010): Opioid analgesic tapentadol (Palexia retard). In: at 2010;41; 103-4.
2. gel-liste.de: Specialist information: active ingredient tapentadol
3. Tzschentke TM et al. Tapentadol hydrochloride: a next-generation, centrally acting analgesic with two mechanisms of action in a single molecule. Drugs Today (Barc), 2009, 45(7), 483-96
4. patient.info: Tapentadol for pain relief