Patent: Patent expired
Producer: Sanofi-Aventis Deutschland GmbH, Cipla, Janssen-Cilag
Dosage form: tablet
Unit of measurement: mg
Candidiasis, Coccidioidomycosis, Blastomycosis, Histoplasmosis, Pityriasis versicolor
Drug class: antifungal medication
Onset of action: 60-120 minutes
Duration of action:
Available in: 0 Pharmacy(s)
ATC-Code: J02AB02, D01AC08, G01AF11
Protein binding: ≥ 80%
Metabolites: N-Deacetyl Ketoconazol
CAS number: 65277-42-1
Drug Bank: DB01026
Molar mass: 531,43 g·mol−1
The active substance, ketoconazole, is believed to exert its antifungal effects by altering cell membranes, resulting in increased membrane permeability, secondary metabolic effects, and growth inhibition.
Although the exact mode of action of ketoconazole has not been fully determined, it has been suggested that the drug's fungistatic activity may result from a disruption in ergosterol synthesis.
Nizoral tablets are taken during meals. The daily dose for adults is 200 mg. If necessary, this dose can be doubled.
The duration of treatment depends on the type of disease.
To prevent fungal infections, take 400 mg per day.
For children weighing 15 to 30 kg, the dose is usually 100 mg. To prevent fungal or yeast infections, children are prescribed 4 to 8 mg per kilogram of body weight once a day.
Qtc interval monitoring
Liver function monitoring
Monitoring of adrenal function
Possible interactions with other drugs
Concomitant inflammatory diseases/
Hypersensitivity to the ingredients
Concomitant use with certain drugs
(see section "Interactions")
Congenital or demonstrated acquired Qtc prolongation
Avoid during pregnancy
Alcohol consumption should be avoided
You can make up for the missed application during the day and continue to use the dose prescribed by your doctor as usual on the following day.
If you suspect an overdose, contact a doctor immediately.
There is a risk of significant interactions. Therefore, medical supervision is recommended.
Nizoral interacts with the following drugs: cyclosporine (Gengraf, Sandimmun, Neoral); paracetamol (Tylenol); digoxin (digitalis, lanoxin); Methylprednisolone (Medrol), tacrolimus (Prograf), loratadine (Alavert, Claritin, Tavist ND), rifampin (Rifadin, Rifater, Rifamate, Rimactane), phenytoin (Dilantin), oral antidrugs, tranquilizers such as midazolam, blood thinners such as warfarin (Coumadin), methotrexate (Rheumatrex, Trexall), cancer drugs, birth control pills or hormone replacement therapy, cholesterol drugs such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and other drugs used to treat HIV or AIDS.
The effect of the drug is influenced by the food.
Always take Nizoral tablets with food as this will help your body use the medicine.
Keep this medicine out of the sight and reach of children.
Store the medicine at normal room temperature.
What are Nizoral tablets used for?
Can you buy Nizoral tablets over the counter?
In what dosage forms can you buy Nizoral?
How do you know the active ingredient in Nizoral?
Nizoral is an antifungal antibiotic used to treat severe fungal or yeast infections. Nizoral kills sensitive fungi by inhibiting the formation of the fungal cell membrane.
The active ingredient in Nizoral is called ketonazole. Nizoral is available in the form of oral tablets, skin cream and shampoo. The tablet is usually taken once a day for a week or more. The cream is applied once or twice a day for 2 to 4 weeks. The shampoo is used twice a week. Treatment with shampoo usually lasts 4 weeks.
The oral tablets Nizoral are prescribed for the treatment and prevention of fungal diseases. The areas of application include:
Nizoral is also used to treat parasitic fungal infections on the skin that cannot be treated with topical medicines or the active ingredient griseofulvin, or in patients who cannot take griseofulvin.
Off-label, Nizoral tablets are used for drug treatment in life-threatening Cushing's syndrome with the aim of reducing cortisol production.
Taking Nizoral tablets for fungal meningitis is not as effective, since the drug poorly penetrates the blood-brain barrier.
Because there is a risk of serious hepatotoxicity, Nizoral tablets should only be taken if the benefit of treatment outweighs the potential risk.
Nizoral tablets are not safe for all patients. Before starting treatment, always tell your doctor the following:
Nizoral tablets can cause serious side effects, including:
1. Liver problems (liver toxicity). There is a risk of serious liver problems that can lead to death or the need for a liver transplant. See your doctor if you have any of the following symptoms after taking it:
2. QT interval prolongation. This prolongation can cause irregular heartbeats, which can be life-threatening. This is possible when Nizoral tablet form is taken at the same time as certain drugs such as quinidine, dofetilide, pimozide, cisapride, disopyramide, methadone, ranolazine and dronedarone. Talk to your doctor about other medicines you are taking before you start taking them. Tell your doctor right away if you feel faint, light-headed, or dizzy, or if your heart is beating irregularly or rapidly. This can talk about QT interval prolongation.
3. Serious heart problems. Contact your doctor if you experience heart palpitations, loss of breath, or dizziness.
Alcohol should be avoided during treatment with Nizoral tablets as alcohol consumption can increase the risk of serious liver problems.
If allergic reactions occur, you should consult a doctor immediately. Symptoms that may indicate an allergic reaction include skin rashes, hives, facial swelling, swollen hands and feet, difficulty breathing, and difficulty swallowing.
Do not combine Nizoral with other antifungal drugs.
Nizoral is available in every pharmacy in Britain. It is also available online. Please note that this drug is subject to prescription in Britain. When you buy Nizoral tablets online, choose a reputable online pharmacy that you trust. Our portal for pharmacy and medicine comparison is used to find a good pharmacy and an affordable price. Use the search box to find the drug you need.
Prefer cream rather than pills.
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