Motilium 10 mg

Available in: 0 Pharmacy(s)

Instructions for use Motilium


Other names: Domperidonum

Bioavailability: 0-50%

ATC-Code: A03FA03, QP51AX24

Protein binding: ≥ 90%

Metabolism: Liver

Metabolites: All inactive

Half-life: 7.5 hours

Excretion: Feces

CAS number: 57808-66-9

PubChem-CID: 3151

Drug Bank: DB01184

ChemSpider: 3039

UNII: 5587267Z69

KEGG: D01745

ChEBI: CHEBI:31515

ChEMBL: ChEMBL219916

ECHA-InfoCard: 100.055.408

Formula: C22H24ClN5O2

Molar mass: 425.92 g·mol−1

How does it work?

Motilium 10 mg tablets contain the active substance domperidone, which belongs to the class of antiemetics and acts as a dopamine antagonist. Domperidone has a blocking effect on peripheral dopamine receptors located in the gastric wall and duodenum. It increases the tone of the lower esophageal sphincter, enhances contractility and prevents the occurrence of duodenogastric reflux.

The antiemetic properties of Motilium are based on a combination of gastrokinetic effects and inhibition of chemoreceptors in the trigger zone of the emesis center. Motilium is able to prevent the development of symptoms such as vomiting and nausea, as well as alleviate these symptoms.

How is it used?

Motilium tablets should be taken in a low dose and should not last longer than a week.

Adults and adolescents from 12 years of age weighing more than 35 kg should take one tablet (Motilium 10 mg) three times a day. The maximum dose is 30 mg per day, ie 3 Motilium tablets. It is recommended to use the drug before meals.

Elderly patients over 60 years of age may seek medical advice before starting intake.

Side effects

Dry mouth

lack of libido

anxiety states



Brustschmerzen beim Mann
Breast tenderness and tenderness

Warnings and Precautions

Beware of the liver problems

Please talk to your doctor before taking Motilium if you have liver problems.

Beware of kidney problems

Consult a doctor before taking Motilium if you have kidney problems.

Other trade names

Oroperidys Domidon Domperidon Generika


Hypersensitivity to the ingredients

Liver diseases

Constant black defecation

Heart failure

Pituitary gland

Blocked or perforated bowel

Periodic severe abdominal pain

Stomach bleeding


Not safe


Alcohol consumption increases the risk of complications

What happens if you miss the dose?

If you miss a dose, you must make up for it as soon as possible. However, you must not take more than your total daily dose in any 24-hour period. double


If you take more than you should, tell your doctor. There could be side effects.


There is a risk of significant interactions. Therefore, medical supervision is recommended.

Unwanted reactions


Skin rash




The effect of the drug is influenced by the food.

If possible, take Motilium before a meal.


Keep this medicine out of the sight and reach of children.

This medicinal product does not require special storage conditions.

Frequently Asked Questions

What is Motilium?

Motilium is a medication used to improve nausea and vomiting.

What is the name of the active ingredient in Motilium tablets?

The Motilium 10mg tablets contain the active ingredient domperidone.

How long can you take Motilium tablets?

The shorter the better. Do not take the tablets for more than 7 days.

Can you buy Motilium without a prescription?

No. In Britain, Austria and Switzerland you cannot buy Motilium without a prescription. This drug requires a prescription in all dosage forms and dosages. You can buy Motilium with a health insurance, private or e-prescription.

What is Motilium for?

Motilium is an original development of the pharmaceutical company Janssen-Cilag AG and belongs to Antiemetika. The active substance in Motilium domperidone is a selective peripheral dopamine antagonist.

This drug is prescribed for adults and adolescents over 12 years old and weighing more than 35 kg for nausea and vomiting caused by toxemia, radiation therapy and infections. It is therefore used for nausea and vomiting during endoscopy and X-ray examinations.

Motilium 10mg works well if there is flatulence, heartburn, gastric laryngitis or upper abdominal pain.

The preparation effectively normalizes the motor function of the stomach and restores the natural rhythm of its work. It is fast acting and has a high safety profile. Its effectiveness has been proven in controlled clinical studies.

In which dosage forms can Motilium be bought?

Motilium can be bought as film-coated tablets, suspension and orodispersible tablets.

Motilium film-coated tablets

  • Motilium oral film-coated tablets are biconvex, round, white to off-white in colour.
  • Active substance: domperidone 10 mg
  • Excipients: Corn Starch, Lactose, Potato Starch, Microcrystalline Cellulose, Magnesium Stearate, Polyvidone, Hydrogenated Cottonseed Oil, Sodium Lauryl Sulfate, Hypromellose.

Motilium drops

  • Motilium drops are available as a white oral suspension. In one package there is a bottle with a suspension and a separate measuring pipette.
  • Active ingredient: domperidone
  • Other ingredients: propyl 4-hydroxybenzoate, microcrystalline cellulose, sodium carboxymethylcellulose, sorbitol, sodium saccharinate, methyl 4-hydroxybenzoate, polysorbate, sodium hydroxide, purified water.

Motilium lingual orodispersible tablets

  • These are round, white and rapidly dissolving tablets.
  • Active ingredient: domperidone
  • Excipients: aspartame, gelatin, mannitol, mint flavor and poloxamer.

Is Motilium available without a prescription in Britain?

Motilium tablets are subject to a prescription in Britain. If you want to buy Motilium from a local pharmacy, you need a valid prescription from your doctor. After the conversation, the species will issue the prescription, which you can then redeem at the local pharmacy.

If going to the doctor is uncomfortable for you, you can have Motilium 10mg prescribed completely legally in a licensed internet pharmacy. You can only buy Motilium over the internet from unlicensed online pharmacies.

What side effects are possible after taking Motilium?

If the recommendations for dosage and duration of treatment are observed, Motilium tablets rarely cause side effects.

Information on the frequency of side effects: very common (≥ 1/10); common (≥1/100 to <1/10); uncommon (≥1/1000 to <1/100); rare (≥1/10000 to <1/1000); rarely seen (<1/10000). When frequency cannot be estimated from the available data, it is reported as not known.

Possible Motilium side effects :

  • on the part of the digestive system: often dry mouth; occasionally diarrhea; rarely functional gastrointestinal disorder, including abdominal pain, changes in appetite, nausea, heartburn, constipation; very rarely short-term intestinal spasms;
  • on the part of the psyche: occasional loss of libido, irritability, nervousness; very rarely depression, restlessness;
  • on the part of the nervous system: occasionally headache, drowsiness, dizziness, extrapyramidal syndrome; very rarely insomnia, thirst, lethargy, akathisia; not known convulsions, restless legs syndrome;
  • on the part of the endocrine system: rarely hyperprolactinemia;
  • on the part of the cardiovascular system: very rarely palpitations, severe ventricular arrhythmia, edema, abnormal heart rate and cardiac arrhythmias;
  • on the part of the reproductive system and mammary glands: occasionally galactorrhea, chest pain; rarely breast enlargement, mammary gland swelling, menstrual disorders; not known Gynaecomastia, amenorrhoea.
  • on the part of the skin: occasionally rash, itching, hives; not known angioedema.
  • on the part of the musculoskeletal system and connective tissue: rarely leg pain;
  • on the part of the urinary system: very rarely dysuria; frequent urination; not known urinary retention;
  • On the part of the visual organs: not known oculogyric crisis;
  • On the part of the immune system: unknown allergic reactions, including anaphylaxis, anaphylactic shock, hypersensitivity.

Other Motilium side effects: conjunctivitis, stomatitis.

In 45 clinical trials where domperidone was taken at high doses, off-label, and long-term, all side effects except dry mouth were more common. This was particularly evident in cases associated with elevated prolactin levels.


  1. Motilium tablets entry at NPS MedicineWise, accessed 22 March 2021.
  2. F De Loose. Domperidone in chronic indigestion
  3. What is domperidone? Wikipedia. URL:
  4. EMA : Motilium
  5. A Boghaert, D Carron, J Gallant, A Stockman. Postoperative vomiting treated with domperidone. A double-blind comparison with metoclopramide and a placebo

Motilium 10 mg



1 Review(s)

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Hello, I am suffering from severe nausea without vomiting. A month ago I took Motilium in tablet form. I noticed an improvement in two days. After 4 days of taking 2 x 1 tablet of 10 mg each, the symptoms were resolved.


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