Motilium 10 mg

What is Motilium for?

Motilium is an original development of the pharmaceutical company Janssen-Cilag AG and belongs to Antiemetika. The active substance in Motilium domperidone is a selective peripheral dopamine antagonist.

This drug is prescribed for adults and adolescents over 12 years old and weighing more than 35 kg for nausea and vomiting caused by toxemia, radiation therapy and infections. It is therefore used for nausea and vomiting during endoscopy and X-ray examinations.

Motilium 10mg works well if there is flatulence, heartburn, gastric laryngitis or upper abdominal pain.

The preparation effectively normalizes the motor function of the stomach and restores the natural rhythm of its work. It is fast acting and has a high safety profile. Its effectiveness has been proven in controlled clinical studies.

In which dosage forms can Motilium be bought?

Motilium can be bought as film-coated tablets, suspension and orodispersible tablets.

Motilium film-coated tablets

• Motilium oral film-coated tablets are biconvex, round, white to off-white in colour.
• Active substance: domperidone 10 mg
• Excipients: Corn Starch, Lactose, Potato Starch, Microcrystalline Cellulose, Magnesium Stearate, Polyvidone, Hydrogenated Cottonseed Oil, Sodium Lauryl Sulfate, Hypromellose.

Motilium drops

• Motilium drops are available as a white oral suspension. In one package there is a bottle with a suspension and a separate measuring pipette.
• Active ingredient: domperidone
• Other ingredients: propyl 4-hydroxybenzoate, microcrystalline cellulose, sodium carboxymethylcellulose, sorbitol, sodium saccharinate, methyl 4-hydroxybenzoate, polysorbate, sodium hydroxide, purified water.

Motilium lingual orodispersible tablets

• These are round, white and rapidly dissolving tablets.
• Active ingredient: domperidone
• Excipients: aspartame, gelatin, mannitol, mint flavor and poloxamer.

Is Motilium available without a prescription in Britain?

Motilium tablets are subject to a prescription in Britain. If you want to buy Motilium from a local pharmacy, you need a valid prescription from your doctor. After the conversation, the species will issue the prescription, which you can then redeem at the local pharmacy.

If going to the doctor is uncomfortable for you, you can have Motilium 10mg prescribed completely legally in a licensed internet pharmacy. You can only buy Motilium over the internet from unlicensed online pharmacies.

What side effects are possible after taking Motilium?

If the recommendations for dosage and duration of treatment are observed, Motilium tablets rarely cause side effects.

Information on the frequency of side effects: very common (≥ 1/10); common (≥1/100 to <1/10); uncommon (≥1/1000 to <1/100); rare (≥1/10000 to <1/1000); rarely seen (<1/10000). When frequency cannot be estimated from the available data, it is reported as not known.

Possible Motilium side effects :

• on the part of the digestive system: often dry mouth; occasionally diarrhea; rarely functional gastrointestinal disorder, including abdominal pain, changes in appetite, nausea, heartburn, constipation; very rarely short-term intestinal spasms;
• on the part of the psyche: occasional loss of libido, irritability, nervousness; very rarely depression, restlessness;
• on the part of the nervous system: occasionally headache, drowsiness, dizziness, extrapyramidal syndrome; very rarely insomnia, thirst, lethargy, akathisia; not known convulsions, restless legs syndrome;
• on the part of the endocrine system: rarely hyperprolactinemia;
• on the part of the cardiovascular system: very rarely palpitations, severe ventricular arrhythmia, edema, abnormal heart rate and cardiac arrhythmias;
• on the part of the reproductive system and mammary glands: occasionally galactorrhea, chest pain; rarely breast enlargement, mammary gland swelling, menstrual disorders; not known Gynaecomastia, amenorrhoea.
• on the part of the skin: occasionally rash, itching, hives; not known angioedema.
• on the part of the musculoskeletal system and connective tissue: rarely leg pain;
• on the part of the urinary system: very rarely dysuria; frequent urination; not known urinary retention;
• On the part of the visual organs: not known oculogyric crisis;
• On the part of the immune system: unknown allergic reactions, including anaphylaxis, anaphylactic shock, hypersensitivity.

Other Motilium side effects: conjunctivitis, stomatitis.

In 45 clinical trials where domperidone was taken at high doses, off-label, and long-term, all side effects except dry mouth were more common. This was particularly evident in cases associated with elevated prolactin levels.

Resources

1. Motilium tablets entry at NPS MedicineWise, accessed 22 March 2021.
2. F De Loose. Domperidone in chronic indigestion
3. What is domperidone? Wikipedia. URL: https://de.wikipedia.org/wiki/Domperidone
4. EMA : Motilium
5. A Boghaert, D Carron, J Gallant, A Stockman. Postoperative vomiting treated with domperidone. A double-blind comparison with metoclopramide and a placebo