modafinil price

What is Modafinil?

Modafinil is a prescription drug used to treat excessive sleepiness caused by narcolepsy. By 2011, it was also approved throughout Britain for the treatment of excessive sleepiness in obstructive sleep apnea syndrome or chronic shift worker syndrome.

Off-label, this drug is used for chronic fatigue syndrome, ADHD, depression or eating disorders.

Modafinil was first developed in France in the early 1990s. When the patent expired in 2011, there are its generics on the market, such as Modalert, Modvigil, Vilafinil, etc.

Since Modafinil was first introduced, it has been one of the most commonly prescribed medications for excessive sleepiness associated with narcolepsy. The reason for this is the lack of serious side effects. For example, unlike amphetamines, modafinil does not cause a sympathomimetic effect and has a substantially low potential for abuse.

Modafinil is considered a well-tolerated drug. According to recent studies, however, it can lead to abuse and addiction. In addition, prolonged excessive sleepiness leads to stress reactions and compromises the immune system.

How and where to buy Modafinil?

In most European countries, modafinil requires a prescription. Britain, Austria and Switzerland are no exception. Here you will not find a classic pharmacy that sells modafinil without a prescription.

Modafinil is readily available over the internet without a prescription. However, online pharmacies located in non-prescription countries can sell modafinil over the counter to anyone who wants it.

Most modafil-containing medicines sold online are exported from India. This is explained by the fact that the laws regarding the sale of medicines in this country are very generous.

In which countries is modafinil available without a prescription?

In Britain, Austria, Switzerland, the USA and in many other countries you cannot buy modafinil without a prescription because it is subject to prescription. Adrafinil-containing drugs, on the other hand, are over-the-counter in some countries. Adrafinil is a prodrug that only becomes effective when it is metabolized to Modafinil.

What Side Effects Can Modafinil Cause?

Modafinil can cause mild or serious side effects. Common side effects include

• Headache,
• Nausea,
• Fear,
• Nervousness,
• Sleep disorders,
• Dizziness,
• dry mouth,
• loss of appetite,
• Diarrhea,
• runny nose,
• Stomach, chest and back pain.

Skin rashes may occur during use. If this side effect occurs, treatment should be discontinued and a doctor consulted.

What are the long-term effects of Modafinil?

The drug should be taken sporadically. If this drug is used long-term, there is a risk of dependence. Tolerance to the active substance can also develop. For this reason, patients take an increased dose to achieve an effect.

To prevent the development of tolerance, the preparation should be taken once a week. This means that the body continues to react "sensitively" to the active substance. If modafinil needs to be taken more frequently for various reasons, it should not be used more than three times a week.

What is the difference between Armodafinil and Modafinil?

Armodafinil, sold under the brand name Nuvigil, is a newer drug compared to modafinil. It was approved in 2007 as the (R)-enantiomer of modafinil. The enantiomers are the molecules that are mirror images of each other (think of your left and right hands as examples). In this way, armodafinil has a slightly different chemical structure than modafinil.

Armodafinil may have a longer half-life compared to modafinil. In some cases, Armodafinil can be considered a stronger drug with better wakefulness effects. While both drugs can have the similar side effects, some side effects may be more common with one drug than the other.

The difference is also in the standard dose. While armodafinil should be taken in a daily dose of 150 mg, the daily dose of modafinil is 200 mg.

Modafinil comes in 100mg or 200mg tablet form. Armodafinil is also available as tablets. Available dosages are 50mg, 150mg, 200mg and 250mg.

Is Modafinil and Ritalin the Same?

No, these are two different drugs. Modafinil and Ritalin are popular central nervous system stimulants. Both Ritalin and Modafinil have similar effects in the brain, all of which help increase feelings of alertness.

In general, Ritalin is better for increasing dopamine levels, while Modafinil is better for stimulating alertness.

In terms of duration of action, modafinil effects last significantly longer than Ritalin effects.

Individual proofs :

1. Robertson P, Jr, Hellriegel ET. Clinical pharmacokinetic profile of modafinil. Clin Pharmacokinet. 2003;42(2):123-137.
2. Entry on Modafinil in Wikipedia
3. Kumar R. Approved and investigational uses of modafinil: an evidence-based review. drug 2008;68(13):1803-1839
4. Medicines.org.uk : Modafinil 100mg tablets
5. Michelle T Cao, Christian Guilleminault. Narcolepsy: Diagnosis and Management
6. B. Boutrel, GF Koob, in Encyclopedia of Sleep, 2013. Basic Sleep Concepts, Science, Deprivation, and Mechanisms
7. Volkow, ND, Fowler, JS, Wang, G, Ding, Y, & Gatley, SJ (2002). Mechanism of action of methylphenidate: insights from PET imaging studies. Journal of attention disorders, 6(1_suppl), 31-43.