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Instructions for use Imovane

Zopiclon

Zopiclon

Other names: [(5RS)-6-(5-Chlorpyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl](4-methylpiperazin-1-carboxylat)

Bioavailability: 50-100%

ATC-Code: N05CF01

Protein binding: ≥ 50%

Metabolism: Liver

Half-life: 5 hours

Excretion: Urine

CAS number: 43200-80-2

PubChem-CID: 5735

Drug Bank: DB01198

ChemSpider: 5533

UNII: 03A5ORL08Q

KEGG: D01372

ChEBI: CHEBI:32315

ChEMBL: ChEMBL135400

ECHA-InfoCard: 100.051.018

Formula: C17H17ClN6O3

Molar mass: 388.81 g·mol−1

How does it work?

The active ingredient is called zopiclone. It belongs to non-benzodiazepines from the group of anxiolytics. Zopiclone increases the activity of a neurotransmitter called GABA in the brain. Neurotransmitters are natural body chemicals that act as messengers between nerve cells. GABA is a neurotransmitter that exerts the effects of a natural "nerve calming" agent. It induces sleep, reduces anxiety and relaxes muscles.

The active substance zopiclone reduces sleep latency and the number of nocturnal awakenings, as well as prolongs sleep duration.

How is it used?

Before starting the intake, the patient should consult a doctor. The dosage is between 3.75 mg and 7 mg. For the elderly, the maximum dosage is 5 mg. This medication should be taken as directed by the doctor in charge to ensure its effectiveness.

The treatment should last from 7 to 10 days, depending on the case. If you continue treatment with Imovane sleeping tablets, there is a high risk of dependence. You should also talk to your doctor before you stop taking it.

Side effects

Schwindel
Drowsiness,
Dizziness

Mundtrockenheit
Dry mouth

Geschmacksstörungen
Taste disorders

headache
nightmares

Kopfschmerzen
Headache

Schwäche
Fatigue

Übelkeit
Nausea

Hautausschlag
Itching

Warnings and Precautions

Tolerance development

Tolerance may develop if Imovane is used for more than 4 weeks.

Mood swings and depression

As with other sleep aids, Imovane is not a treatment for depression and may even mask its symptoms. Any underlying cause of insomnia should also be addressed prior to symptomatic treatment to avoid treating the potentially serious consequences of depression.

Withdrawal symptoms

Discontinuation of Imovane should be gradual, otherwise withdrawal symptoms may develop.

Other trade names

Optidorm Zopitin Zopiclodura Ximovan Somnosan Somnal

Contraindications

Hypersensitivity to the ingredients

Severe muscle weakness

Severe breathing disorders

Sleep apnea syndrome

Severe liver damage

This medicine should not be used in children and adolescents under 18 years of age.

Pregnancy

Avoid during pregnancy

Alcohol

Alcohol consumption increases the side effects of medication

What happens if you miss the dose?

Do not apply a double dose if you have forgotten the previous application, but continue the application as before.

Overdose

Serious side effects can occur after taking excessively high doses. If you experience severe side effects, seek medical help immediately.

Interactions

There is a risk of serious interactions. Therefore, regular medical monitoring is required.

Unwanted reactions

Drowsiness

Dizziness

Food

Food does not affect the effects of the drug.

Storage

Keep this medicine out of the sight and reach of children.

Do not store above 25°C.

Frequently Asked Questions

How fast does Imovane work?

Usually you feel sleepy within 30-60 minutes after taking Imovane.

How long does Imovane work?

The effects of Imovane (zopiclone) last for five to ten hours.

How long can Imovane be taken?

Imovane should only be taken as needed when you are having trouble sleeping. The duration of treatment is 7 to 10 consecutive days.

How do you stop Imovane?

After stopping abruptly, rebound insomnia and withdrawal symptoms may develop. Therefore, it is recommended to gradually reduce the Imovane dose and inform the patient about this.

How many Imovan sleeping pills are deadly?

Imovane overdose is not fatal on its own. If Imovane is taken at the same time as other centrally acting drugs or alcohol beverages, this can cause life-threatening potentiation.

Can you buy Imovane without a prescription?

No, Imovane is a prescription drug and requires a prescription.

Where to buy Imovane at low price?

Imovane can be bought in both stationary pharmacies and online pharmacies. To get Imovane cheap, order it online. Use our website to compare Imovane prices.

What is Imovane?

Imovane is a prescription sleep medication for the treatment of major insomnia in people 18 years and older. The active ingredient in Imovane Zopiclone belongs to a class of hypnotics and is used for short-term use. It has been approved since 1994. Imovane is classified as a Z-drug (new generation sedative).

In general, it is used in cases of difficulty falling asleep, difficulty staying asleep, unrefreshing sleep and early morning awakenings. It helps you fall asleep faster and stay asleep throughout the night.

This sleep aid is available in 3.75 and 7.5 mg film-coated tablets. Imovane price depends on dosage and package size, the more tablets you buy, the cheaper Imovane price.

Can you buy Imovane (zopiclone) without a prescription?

The sleeping pills Imovane (Zopiclon) require a prescription. They may only be used after consultation with the doctor treating you. This is explained by the fact that all Z-Drugs should only be taken when clearly indicated, in the smallest possible dosage and over the shortest possible period of time.

If you want to buy Imovane without a prescription, you should use the services of an online vendor. However, there is a risk for the fakes.

Imovane sleeping tablets work better with these tips

  1. Avoid caffeine, alcohol and nicotine.
  2. Avoid a large and fatty dinner just before bedtime.
  3. Keep your wake up and go to bed times regular every day. Avoid sleeping during the day.
  4. Exercise regularly (during the day)
  5. Avoid cognitively stimulating recreational activities before bedtime.
  6. Provide a quiet and comfortable sleeping environment (e.g. comfortable temperature, dark room, no pets in bed).
  7. Only use your bedroom to sleep.

Can Imovane sleeping tablets be addictive?

When prescribing Imovane sleeping tablets, it should be borne in mind that treatment with these sleeping pills (even in therapeutic doses) can lead to the development of physical and psychological dependence. The risk of dependence is minimal if the treatment lasts no more than 4 weeks.

The risk of addiction or abuse can be increased by:

  • an overdose
  • an extension of treatment
  • alcohol and/or drug abuse, also in the past
  • taking alcohol or other psychotropic drugs.
  • severe personality disorders in the patient.

If physical dependence develops, stopping treatment suddenly can cause withdrawal symptoms. Such withdrawal symptoms include headaches, muscle aches, extreme restlessness, tension, anxiety, confusion, and irritability. In severe cases, the following symptoms may occur: depersonalization, derealization, hyperacusis, hypersensitivity to light or noise, numbness, tingling, hallucinations or epileptic seizures.

What to consider before buying Imovane online?

Some medicines are not suitable for people with certain medical conditions. For this reason, before taking Imovane sleeping tablets, it is important to tell your doctor about the following:

  • that you are pregnant or breastfeeding
  • that you have breathing problems or suffer from sleep apnea;
  • that you suffer from myasthenia gravis or any other condition that causes muscle weakness, especially if it causes difficulty breathing;
  • that you have ever been addicted to medication;
  • that you have a mental health problem;
  • that you have impaired kidney or liver function;
  • if you have ever had an allergic reaction to a medicine;
  • if you are taking or using other medicines.

There is a risk of anterograde amnesia, particularly when sleep is interrupted or after a long interval between taking Imovane and bedtime. To reduce this risk, you need to take a pill immediately before bedtime.The drug is not indicated for the treatment of depression and can even mask its symptoms.

In some cases, these sleeping pills can cause behavior changes, which sometimes include worsening symptoms of depression. In this case, contact your doctor immediately. Thoughts of suicide or self-harm are also part of behavioral changes.

Can Imovane be combined with other medicines?

Because of possible drug interactions, your doctor or pharmacist should know which medicines you are already taking. Below are some of the interactions provided.

Painkillers: If you need to take a painkiller with Imovane, it can be paracetamol or ibuprofen. Avoid codeine and dihydrocodeine.
Opioids. If you are on treatment with an opioid, such as a strong pain reliever such as morphine, tramadol tablets, dihydrocodeine or fentanyl, a cough medicine such as codeine or pholcodine, or an addiction treatment drug such as methadone, taking Imovane may also be prone to depression sleep so that you cannot breathe properly or have difficulty getting up.

Medicines for infections: co-administration can increase the amount of zopiclone in the blood, which can increase the sedative effect and the risk of side effects.

If you are taking clarithromycin, ketoconazole, erythromycin, HIV protease inhibitors (such as ritonavir) or itraconazole, Imovane dose reduction is required.

Other medicines that may make you drowsy: the following medicines increase the sedative effects of Imovane (zopiclone) and must not be combined:

  • antipsychotics, e.g. haloperidol and chlorpromazine;
  • antihistamines that make you sleepy, such as promethazine, chlorphenamine, hydroxyzine, or cinnarizine;
  • benzodiazepines, e.g. temazepam, diazepam;
  • barbiturates such as phenobarbital, amobarbital, primidone;
  • MAO inhibitors such as phenelzine;
  • other sleeping pills, e.g. B. zolpidem, melatonin, zaleplon;
  • tricyclic antidepressants, e.g. amitriptyline, mirtazapine;
  • tizanidine;
  • gabapentin;
  • baclofen;
  • pregabalin;
  • lofexidine.

The effectiveness of sleeping pills Imovane 7 5 is reduced when taken concomitantly with carbamazepine, phenytoin, phenobarbital, rifampicin, or St. John's wort.

Resources

  1. Entry on zopiclone in Wikipedia.
  2. Noble S., Langtry HD, Lamb HM Zopiclone. An update of its pharmacology, clinical efficacy and tolerability in the treatment of insomnia. Drugs, 1998, 55(2), 277-302.
  3. Poser, Wolfgang et al. (2006): Drug dependence (sedatives, hypnotics, analgesics, psychostimulants), , 271-307.
  4. Nevio Cimolai, MD FRCPC. zopiclone. Is it a pharmacologic agent for abuse?
  5. Drugs.com : Zopiclone Advanced Patient Information.
Reviews

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4.1

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Strong sleeping pills with great effects. Have been taking Imovane for insomnia for 3 weeks. I got along great with these sleeping pills.

15.05.2022

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