Flagyl tablets

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Instructions for use Flagyl

Metronidazol

Metronidazol

Other names: 2-Methyl-5-nitroimidazol-1-ethanol

Bioavailability: 50-100%

ATC-Code: A01AB17, D06BX01, G01AF01

Protein binding: ≥ 20%

Metabolism: Liver

Metabolites: Hydroxymetronidazol

Half-life: 8 hours

Excretion: Urine

CAS number: 443-48-1

PubChem-CID: 4173

Drug Bank: DB00916

ChemSpider: 4029

UNII: 140QMO216E

KEGG: D00409

ChEBI: CHEBI:6909

ChEMBL: ChEMBL137

ECHA-InfoCard: 100.006.489

Formula: C6H9N3O3

Molar mass: 171.156 g·mol−1

How does it work?

The active substance in Flagyl is called metronidazole. It works by killing the specific bacteria and unicellular organisms that cause infection.

How is it used?

Flagyl tablets are taken by mouth. In order for Flagyl to be effective in killing harmful bacteria, it is important to maintain a constant plasma concentration of the active substance metronidazole. Therefore, one tablet should be taken at regular intervals. Take Flagyl with plenty of water, with or without food. The preparation should only be taken for a short time and for a maximum of 10 days.

  • For amoebic dysentery : 750 mg Flagyl three times a day for 5-10 days.
  • For amoebic liver abscess : 500-750 mg orally 3 times a day for 5-10 days.
  • For anaerobic infections : 7.5 mg/kg orally every 6 hours for 7 to 10 days; the maximum daily dose is 4 grams.
  • For Clostridium difficile infection : 250-500 mg Flagyl four times a day or 500-750 three times a day.
  • For giardiasis : 250 mg three times a day for 5 days.
  • For infections caused by Helicobacter pylori : 800-1500 mg orally daily for several days in combination with other drugs.
  • For pelvic inflammatory disease : 500 mg twice a day for 14 days in combination with other preparations.
  • For trichomoniasis : 2 g Flagyl as a single dose or 1 g divided into 2 single doses.

Side effects

Schwindel
Dizziness

Kopfschmerzen
Headache

Magenschmerzen
upset stomach

Übelkeit
Nausea,
Vomit

Appetitprobleme
loss of appetite

Durchfall
Diarrhea

Verstopfung
Constipation

Geschmacksstörungen
Taste disorders

Warnings and Precautions

Beware of kidney problems

Caution is advised if you have kidney disease, especially if you require dialysis treatment.

Beware of the liver problems

if you have ever had liver disease, seek medical advice before taking Flagyl.

Be careful with epilepsy

If you suffer from epilepsy or have a history of seizures, caution should be exercised during treatment with Flagyl.

Other trade names

Clont Elyzol Metrosa Rosiced Vagi-Metro Vagimid Anaerobex Arilin Dumozol Nidazea Rosalox Perilox Rozex  Trichex

Contraindications

Hypersensitivity to the ingredients

Pregnancy

Kontraindiziert im ersten Schwangerschaftsdrittel

Lactation

Pregnancy

Avoid during pregnancy

Alcohol

Alcohol consumption increases the risk of complications

What happens if you miss the dose?

If you miss a dose, you must make up for it as soon as possible. However, you must not take more than your total daily dose in any 24-hour period. double

Overdose

If you suspect an overdose, contact a doctor immediately.

Interactions

There is a risk of significant interactions. Therefore, medical supervision is recommended.

Unwanted reactions

Allergic reaction

Confusion

Hallucinations

Liver damage

Food

Food does not affect the effects of the drug.

Storage

Do not store above 25°C.

Store in the original package in order to protect from light and moisture.

Frequently Asked Questions

What is Flagyl?

Flagyl is a medicine against the infections caused by bacteria and parasites. The active ingredient is metronidazole. Flagyl is indicated for both adults and children.

Is Flagyl an antibiotic?

Yes, Flagyl is a broad spectrum antibiotic that contains the active ingredient metronidazole.

What side effects can Flagyl cause?

Like all medicines, Flagyl can also cause side effects such as headaches, diarrhea, nausea, stomach upset, taste disturbances, etc.

Is Flagyl carcinogenic?

According to a study, taking Flagyl can increase the risk of stomach cancer in people infected with Helicobacter pylori.

Why buy Flagyl?

Flagyl is an antibacterial drug that belongs to broad-spectrum antibiotics. It is used to treat bacterial infections and prevent them during surgical interventions. For example, this medicine can be used for the following infections:

  • Protozoal infections: extraintestinal amebiasis, including amebic liver abscesses, intestinal amebiasis (amoebic dysentery), trichomoniasis, balantidiasis, giardiasis, cutaneous leishmaniasis, trichomonas vaginalis, trichomoniasis;
  • Bacteroides infections (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): bone and joint infections, CNS infections including meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis;
  • Infections caused by Clostridium, Peptococcus and Peptostreptococcus: abdominal cavity infections (peritonitis, liver abscess), pelvic organ infections (endometritis, fallopian tube and ovarian abscess, vaginal vault infections);
  • antibiotic-associated colitis associated with the use of antibiotics;
  • gastritis or duodenal ulcers caused by Helicobacter pylori (these infections require combination therapy);
  • Prevention of postoperative complications (especially surgical interventions in the gastrointestinal tract, appendectomy, gynecological operations).

Depending on the area of application, the antibiotic is used for up to 10 days.

What is the name of the active ingredient in Flagyl?

The active substance in Flagyl is called metronidazole and this substance belongs to nitroimidazoles. It was developed at Rhône-Poulenc starting from azomycin. Metronidazole is a prodrug and has bactericidal and antiparasitic properties.

It distributes well into tissues and has a half-life of eight hours (six to ten hours).

In what strengths and dosage forms is Flagyl available on the market?

The preparation Flagyl is available in the form of film-coated tablets, vaginal suppositories and solution for infusion. The dosages vary depending on the dosage form. So there is Flagyl as tablets of 250mg, 400mg and 500mg in the trade. The infusion solution is offered in 500 mg dosage. 100 milligrams is the potency for the vaginal suppositories.

How to buy Flagyl?

Bacterial infection, especially vaginal infection, is uncomfortable and embarrassing. That is why more and more people are looking for the effective medicines on the net. You can find several preparations against it on the Internet. One of the effective means is Flagyl in tablet form. The tablets are available both over the counter and with an online prescription. Ordering Flagyl without a prescription is not recommended.By ordering this drug online, it will be sent directly to your home in a plain packaging.

What side effects can Flagyl cause?

When used properly, Flagyl is usually well tolerated. Possible side effects include nausea, loss of appetite, headache, metallic taste in mouth, rash, abdominal cramps, diarrhea, vomiting, dry mouth, dark urine, constipation, dizziness, nasal congestion, etc.

Unpleasant and serious side effects can occur while taking it, such as fever, brain disease, painful urination, cystitis, decreased libido, stomatitis, tingling, mouth sores, pelvic pain, glossitis, and proctitis. These side effects are usually rare.

Flagyl should be discontinued if you have any of the following symptoms: peripheral neuropathy, seizures, aseptic meningitis, encephalopathy, colon cancer associated with Crohn's disease, and nerve damage resulting in numbness and tingling in the extremities.

Price comparison for Flagyl

The price depends on the dosage, dosage form and package size in which you buy the drug Flagyl. The basic price for the 400 mg film-coated tablets starts at €1.03 for 1 piece. Flagyl 500 mg price for a pack of 12 starts at €14.75.

Individual proofs:

  1. What are the side effects of metronidazole? URL: https://www.medicinenet.com/
  2. Hernández ceruelos A, Romero-quezada LC, Ruvalcaba ledezma JC, López contreras L. Therapeutic uses of metronidazole and its side effects: an update. Eur Rev Med Pharmacol Sci. 2019;23(1):397-401.
  3. Löfmark S, Edlund C, Nord CE Metronidazole is still the drug of choice for treatment of anaerobic infections. Clin Infect Dis, 2010, 50 Suppl 1, S16-23 Pubmed
  4. V Miljkovic, B Arsic, Z Bojanic, G Nikolic, Lj Nikolic, B Kalicanin, V Savic. Interactions of metronidazole with other medicines: a brief review
  5. bnf.nice.org.uk : Metronidazole interactions
Reviews

Flagyl tablets

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I suffer from bacterial vaginosis. I was prescribed the 7-day regimen of Flagyl. Today is the 4th day of treatment. I feel good. I was warned by my doctor about alcohol and side effects. After the second pill I took, I got the abdominal pain and minimal diarrhea. I expected it to continue like this, but so far I feel healthy and awake. All medications have side effects and my experience with Flagyl has been positive so far.

25.04.2022

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