Buy Cymbalta

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Instructions for use Cymbalta



Bioavailability: 0-50%

ATC-Code: N06AX21

Protein binding: ≥ 90%

Metabolism: Liver

Half-life: 12 hours

Excretion: Urine

CAS number: 116539-59-4

PubChem-CID: 60835

Drug Bank: DB00476

ChemSpider: 54822


KEGG: D07880

ChEBI: CHEBI:36795


ECHA-InfoCard: 100.116.825

Formula: C18H19NOS

Molar mass: 297,42 g·mol−1

How does it work?

The active substance in Cymbalta is called duloxetine. This drug works by inhibiting the reuptake of norepinephrine and serotonin and by inactivating transmitters. Duloxetine is absorbed via the gastrointestinal tract. Oral bioavailability is 32%-80%. The maximum plasma level is reached after about 6 hours.

The plasma half-life of duloxetine and its metabolites is 12 hours. Duloxetine is mainly excreted by the kidneys and partly in the faeces.

How is it used?

Cymbalta is usually taken once a day, preferably at the same times, and with or without food. Usually, patients start their treatment on a low dose. The dose is slowly increased over several weeks. It usually ranges from 30 mg to 120 mg. Only your doctor can determine the right dose for you.

The capsule should be swallowed whole.

For depression and pain associated with diabetic neuropathy, the dose of 60 mg once a day is usually prescribed by the doctor.

For the treatment of generalized anxiety disorder, the starting dose is 30 mg daily, increasing gradually to 60 mg.

Side effects




Dry mouth

Decreased appetite

sleep disorders


Blurred vision


high blood pressure


Stomach pain



Excessive sweating

Muscle aches

Warnings and Precautions

Possible interactions with other drugs

Caution should be exercised when Cymbalta is administered concomitantly with other medications (see "Does Cymbalta interact with other drugs and drugs?").

Beware of kidney problems

If you suffer from kidney disease, you should take this supplement with caution.

Other trade names

Yentreve Xeristar Duloxetin


Hypersensitivity to the ingredients

Liver diseases

Kidney diseases

Simultaneous administration with MAO inhibitors

Concomitant use with certain drugs

This is about fluvoxamine, ciprofloxacin, enoxacin and other duloxetine-containing drugs.


Not safe


Alcohol consumption should be avoided

What happens if you miss the dose?

You can make up for the missed application during the day and continue to use the dose prescribed by your doctor as usual on the following day.


If you suspect an overdose, contact a doctor immediately.


There is a risk of significant interactions. Therefore, medical supervision is recommended.

Unwanted reactions

Allergic reaction

Suicidal thoughts


Food does not affect the effects of the drug.


Keep this medicine out of the sight and reach of children.

Frequently Asked Questions

What is Cymbalta?

Cymbalta is an antidepressant drug used to treat depression and generalized anxiety disorder. It is available in 30 mg and 60 mg capsules. The active substance is called duloxetine.

Can Cymbalta cause weight loss or gain?

Cymbalta can cause loss of appetite with weight loss. Rarely, patients may gain weight.

How long does the withdrawal symptom last after stopping Cymbalta?

Draw-in symptoms can last a few days to 6 weeks after stopping Cymbalta.

How long does it take for Cymbalta to work?

The Cymbalta effect only sets in after about 1 to 2 weeks.

What does the price of Cymbalta depend on?

Cymbalta price depends on three factors, namely dosage, package size and pharmacy where you buy the drug.

Cymbalta 60 mg price vs Cymbalta 30 mg price

The lower dosage is, the cheaper Cymbalta price is.

What kind of medicine is Cymbalta?

Cymbalta is a prescription antidepressant. It contains the active substance duloxetine, which belongs to the group of selective serotonin-norepinephrine reuptake inhibitors.

Cymbalta is approved by the EMA to treat a variety of conditions. It is suitable for adults suffering from depressive episodes; generalized anxiety disorder or pain associated with diabetic neuropathy.

It is also widely applied in pediatrics. This antidepressant can be used to treat generalized anxiety disorder in children over the age of 7 and fibromyalgia in children over the age of 13.
Compared to other drugs from the serotonin-norepinephrine reuptake inhibitor group, Cymbalta does not have a major impact on blood pressure changes. However, it may take several weeks before you feel the full effect of the medicine on your mood.

Cymbalta is available as enteric-coated hard capsules. The capsules are available in 2 strengths: 30 milligrams and 60 milligrams. Cymbalta is also available as a generic drug called duloxetine.

Cymbalta price at a glance

The price of Cymbalta depends on several factors. The manufacturer plays a role here. Since Cymbalta is generic today, it costs less than the brand name. The price is related to the dosage and package size. The more tablets in a pack, the lower the price.

Table: Cymbalta price 30 mg vs 60 mg

pack size Cymbalta 30 mg price Cymbalta 60 mg price
28 tablets from €22.36 from €22.99
98 tablets from €31.42 from €43.28

How long do Cymbalta side effects last?

How long this or that side effect of Cymbalta lasts depends on the side effect itself. Also, your risk of certain side effects may be higher when you first start taking the drug. For example, the risk of suicidal thoughts or behavior may be highest in the first few months after taking Cymbalta or after a dose change. However, these thoughts or behaviors can occur at any time while you are taking Cymbalta.

The risk of orthostatic hypotension is also highest in the first week after taking Cymbalta. Some side effects may go away once the drug is stopped. The other side effects like liver failure may not go away after stopping the drug. If you have the questions about the risk of Cymbalta side effects, consult your doctor or pharmacist.

Can you combine Cymbalta with alcohol?

Taking Cymbalta is associated with the risk of liver damage. And drinking alcohol while on this intake can increase this risk. Therefore, alcohol consumption should be avoided or limited during treatment with Cymbalta.

Consult your doctor immediately if you have any of the following symptoms as these may be symptoms of liver damage:

  • chills;
  • fever;
  • joint pain or swelling;
  • unusual bleeding or bruising;
  • excessive tiredness or weakness;
  • rash or itching;
  • nausea;
  • vomit;
  • loss of appetite;
  • dark urine;
  • jaundice.

Does Cymbalta interact with other drugs and medicines?

Because of drug interactions, caution should be exercised when combining Cymbalta with other drugs.

Cymbalta should not be taken at the same time as or within 2 weeks of taking MAOIs. These include tranylcypromine (Jatrosom), rasagiline (Azilect), and selegiline (Movergan, Antiparkin).

Such drugs as cimetidine (CimLich), ciprofloxacin (Ciloxan), fluoxetine (Prozac, Generic Fluoxetine), fluvoxamine (Fevarin, Luvox), paroxetine (Allenopar, Paroxalone) may increase plasma levels and affect the effects of duloxetine.

Rarely, there is an increased risk of serotonin syndrome when Cymbalta is used concomitantly with other medicines that increase serotonin. Such drugs include other antidepressants, anti-migraine drugs from the triptan group (e.g. Imigran) and some painkillers (e.g. Tramadol, Ultram), antibiotic Zyvoxide and amphetamines.

Co-administration with other drugs that can cause bleeding (e.g. ibuprofen, warfarin and aspirin) increases the effects of these drugs.

What happens if you just stop using Cymblta?

Abrupt discontinuation of treatment with Cymblta must be avoided as this can trigger pronounced discontinuation phenomena (anxiety, tinnitus, agitation, confusion). Discontinuation should generally be gradual (over 2 weeks).


  1. What Other Medications May Interact With Duloxetine? National Alliance on Mental Illness. URL:
  2. Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30
  3. Package leaflet of CYMBALTA 60 mg gastro-resistant capsules, hard

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1 Review(s)

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I`ve been taking Cymbalta since 2016, it replaces venlafaxine. First I took 90 mg, 1 year ago my depression got worse and since then I`ve had the maximum dose (120 mg), I hope to be able to lower it. I like Cymbalta, I`ve adapted well. I also use topiramate from time to time.


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