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Instructions for use Advil



Other names: (RS)-2-(4-Isobutylphenyl)propionsäure

Bioavailability: 50-100%

ATC-Code: C01EB16

Protein binding: ≥ 90%

Metabolism: Liver


Half-life: 2-4 hours

Excretion: Urine

CAS number: 15687-27-1

PubChem-CID: 3672

Drug Bank: DB01050

ChemSpider: 3544


KEGG: D00126



ECHA-InfoCard: 100.036.152

Formula: C13H18O2

Molar mass: 206,28 g·mol−1

How does it work?

Advil inhibits cyclooxygenases, the enzymes that help produce prostaglandins and thromboxane. Prostaglandins are involved in mediating pain and fever. Thromboxane is involved in promoting blood clots and cyclooxygenases also help maintain a protective lining of the stomach lining.

The therapeutic effects of Advil for pain relief and fever reduction are due to the reduced effect of prostaglandins. The gastrointestinal side effects of Advil are also related to its inhibition of cyclooxygenases and thromboxane.

The effects usually last four to eight hours.

How is it used?

The tablets are taken orally with enough water. Take Advil with food or milk to relieve stomach upset.

The recommended dose for adults and adolescents 12 years and older is one 200 mg tablet every 4 to 6 hours until symptoms disappear. If the pain or fever does not go away, you can take 2 tablets. An Advil overdose can damage your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses).

The child's dose of Advil depends on their age and weight.

Side effects

upset stomach,






Warnings and Precautions

risk of heart attack

These painkillers can increase the risk of heart attack or stroke. The risk increases with higher doses or prolonged use of Advil.

Possible interactions with other drugs

Advil can interact with many drugs, including antihypertensive drugs and anticoagulants.

Other trade names

Migränin Ibuprofen Aktren Neuralgin Neuralgin extra


Hypersensitivity to the ingredients

Stomach ulcers

Heart problems such as a heart attack, irregular heartbeat, angina, chest pain, aortic stenosis, or heart failure

Kidney diseases

Liver diseases


Not safe

Taking Advil during the last 3 months of pregnancy may harm an unborn baby. Do not use this medicine without medical advice if you are pregnant.


Alcohol consumption should be avoided

What happens if you miss the dose?

If you miss a dose, do not take twice as much the next time, but take it as described in the dosage instructions or as instructed by your doctor


If you take more than you should, gastrointestinal upset may occur.


There is a risk of significant interactions. Therefore, medical supervision is recommended.

Unwanted reactions

Allergic reaction


Skin rash


The effect of the drug is influenced by the food.


Keep this medicine out of the sight and reach of children.

Frequently Asked Questions

What pain does Advil help with?

Most people find Advil to be very good at helping with mild to moderate pain such as a headache, back pain, menstrual cramps, toothache, or arthritis.

Can I take Advil if I have a cold?

You can order Advil tablets online and take them when you have a cold, but it is not a decongestant. Advil will help reduce fever and reduce pain to make you feel more comfortable, but it won't help with nasal congestion.

How many pills to take for a headache?

Regardless of your pain, the dosage for Advil is the same. Adults and those over 12 years old should take one 200 mg tablet every four to six hours while they are in pain. If after an hour you feel you need more, you should take a second tablet. You can take up to six single doses in any 24-hour period.

What are the most common side effects?

Advil is a very safe medicine, but you should not take it long-term or in high doses as it may increase the chances of having a stroke, heart attack, or an episode of internal bleeding. Older people are more likely to have stomach or intestinal bleeding. These side effects can occur without warning and in some cases can be fatal.

Where to order Advil tablets online?

Although Advil is available over the counter at any local pharmacy, more and more people prefer to order Advil tablets online. The reason for this is cheaper price than in stationary pharmacies. All online pharmacies that have Advil in their range are available on this page.

Why order Advil?

Advil, an over-the-counter drug, is a trade name for ibuprofen, a nonsteroidal anti-inflammatory drug used to treat mild pain.

Each Advil tablet contains 200 mg ibuprofen. Ibuprofen also comes in a generic form and is the active ingredient in another supplement, Motrin.

Advil is used for a variety of medical conditions. You can use it for pain relief, reducing inflammation, and lowering your body temperature when you have a fever. It is taken in the following cases:

  • cold
  • headache
  • menstrual pain
  • toothache
  • back pain
  • Muscle aches
  • mild arthritis pain.

It should be noted that Advil is used to temporarily relieve symptoms, which means it will not cure the condition.

What dosage forms is Advil available in?

You can order Advil in the following dosage forms: tablets, syrup, suspensions and liqui gel. In addition to these application forms, there is the substance ibuprofen in the form of sustained-release tablets, soft capsules, suppositories, effervescent granules and creams on the German market.

How to order Advil tablets online?

You can buy Advil online without a prescription. However, if you have any concerns about side effects, interactions with any medications you are taking, or any other questions about Advil, you should consult a doctor or pharmacist before taking it.

Please note that you will not find Advil in the stationary pharmacies in Germany. Throughout Germany, ibuprofen is offered under other trade names.

Can I drink alcohol while taking Advil?

It is recommended not to take Advil tablets with alcohol. Advil is capable of causing severe stomach bleeding, especially when taken in higher doses for a long period of time. This risk increases if the patient consumes 3 or more alcohol drinks per day while taking Advil.

What side effects are possible after taking Advin?

The medicine Advil can cause an upset stomach. To reduce the risk of stomach upset, this medication should be taken with food or milk.

Bleeding can also occur during use, most commonly stomach bleeding. It is important to recognize the symptoms of stomach bleeding, such as dark stools, tiredness, dizziness and bloody vomiting, in good time.

The other possible side effects of Advil tablets are easy bruising, blood in the urine and bleeding in the eye.

Rarely, it can cause allergies, hives, facial swelling, asthma, rash, blisters, or shock.

What needs to be considered during treatment with Advil?

Advil may increase the risk of kidney damage. This risk is increased in patients with dehydration or volume depletion.

If you have an underlying kidney disease, e.g. B. due to diabetes, high blood pressure or another cause, you should avoid Advil. If you need to take it, please make sure you are not dehydrated.

This pain reliever can also lower sodium levels and increase blood potassium levels. If you are taking the blood pressure lowering medications that tend to increase potassium levels or decrease sodium levels, refrain from taking Advil.

Advil can also induce volume overload. Therefore, simultaneous administration with medication for drainage is not recommended.

These painkillers can increase the risk of heart attack or stroke. The risk increases with higher doses or prolonged use of Advil.

Advil can interact with other medicines, including blood pressure medicines and anticoagulants. It's important to tell your doctor or pharmacist if you're taking any other medications that may interact with Advil. Caution is advised not only with prescription but also with herbal medicines. For example, Advil interacts with Ginkgo biloba, which is used for memory problems.

These are just some of the medicines and substances that interact with Advil: beta-blockers (used to treat high blood pressure); Antidepressants, diuretics, etc.

If you suffer from asthma, you should consult a doctor or pharmacist before ordering Advil. This is because the active ingredient, ibuprofen, can cause or worsen asthma symptoms or cause inflammation of the inside of your nose.


  1. What is Advil? URL: https://www.drugs.com/advil.html
  2. Ibuprofen entry in NHS, retrieved 24 January 2021.
  3. Kim D. Rainsford: Ibuprofen: A Critical Bibliographic Review. CRC Press, 2003, ISBN 0-203-36258-6, History and Development of Ibuprofen, pp. 1-22.
  4. Healthline.com : Effects of Using Ibuprofen with Alcohol
Terry Evans
Assistant doctor and freelance author
In addition to his work as an assistant doctor at the Urology Clinic in Augsburg, he has been supporting the editors of the health service as a freelance author since January 2021.

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1 Review(s)

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I take Advil for my migraines (about 2-3 times a month), which in severe cases mean I have to go to bed and vomit. Since I've been taking Advil whenever the migraine starts, I haven't had any more migraine problems.


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